Statistical mechanics of thermal denaturation of DNA oligomers
نویسندگان
چکیده
منابع مشابه
Effect of defects on thermal denaturation of DNA oligomers.
Effect of defects on the melting profile of short heterogeneous DNA chains is calculated using the Peyrard-Bishop Hamiltonian. On-site potential on a defect site is represented by a potential that has only a short-range repulsion and a flat part without well of the Morse potential. Stacking energy between two neigbouring pairs involving a defect site is also modified. The results are found to b...
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A unifying theory of the denaturation transition of DNA, driven by temperature T or induced by an external mechanical torque Γ is presented. Our model couples in a geometrical way the hydrogen-bond opening and the untwisting of the helicoidal molecular structure. Using the transfer matrix method, we show that denaturation corresponds to a first-order phase transition from BDNA to dDNA phases an...
متن کاملStatistical mechanics of a nonlinear model for DNA denaturation.
In a letter [1] Peyrard and Bishop investigated the statistical mechanics of a simple lattice model for the denaturation of the DNA double helix. The model consists of two degrees of freedom u n and v n corresponding to the transverse displacements of the bases, i.e., displacements along the direction of the hydrogen bonds, which connect the two bases in a pair. The Hamiltonian for the model is...
متن کاملThermal denaturation of A-DNA
The DNA molecule can take various conformational forms. Investigations focus mainly on the so-called ‘B-form’, schematically drawn in the famous paper by Watson and Crick [1]. This is the usual form of DNA in a biological environment and is the only form that is stable in an aqueous environment. Other forms, however, can teach us much about DNA. They have the same nucleotide base pairs for ‘bui...
متن کاملThermal denaturation of a helicoidal DNA model.
We study the static and dynamical properties of DNA in the vicinity of its melting transition, i.e., the separation of the two strands upon heating. The investigation is based on a simple mechanical model which includes the helicoidal geometry of the molecule and allows an exact numerical evaluation of its thermodynamical properties. Dynamical simulations of long-enough molecular segments allow...
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ژورنال
عنوان ژورنال: Pramana
سال: 2003
ISSN: 0304-4289,0973-7111
DOI: 10.1007/bf02708314